Dorsal CA1 hippocampal place cells form a multi-scale representation of megaspace
نویسندگان
چکیده
منابع مشابه
Discordance of spatial representation in ensembles of hippocampal place cells.
The extent to which small ensembles of neighboring hippocampal neurons alter their spatial firing patterns concurrently in response to stimulus manipulations was examined in young adult rats as well as in aged rats with and without memory impairment. Recordings from CA1 and CA3 cells were taken as rats performed a spatial radial-maze task that employed prominent distal visual stimuli attached t...
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The generality of the place-learning impairment associated with hippocampal system damage was challenged using methods of training that permitted subjects to form an individual association between the place of escape and a particular navigational route in an open-field water maze. Both normal rats and rats with fornix lesions (FX rats) acquired this task rapidly, although FX rats were slightly ...
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Place-specific discharge of hippocampal cells was monitored while rats performed daily 15 trials of a spatial memory task. During the intertrial interval between trials 5 and 6, the lateral dorsal nucleus of the thalamus (LDN) was reversibly inactivated. Choice accuracy on the maze became impaired, and many hippocampal place fields became disrupted. These data support the proposition that the L...
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Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the original unconditioned stimulus. While the hippocampus has received extensive attention for its role in learning and memory processes, less is known regarding its role in drug-reward...
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A computer model of learning and representing spatial locations is studied. The model builds on biological constraints and assumptions drawn from the anatomy and physiology of the hippocampal formation of the rat. The emphasis of the presented research is on the usability of a computer model originally proposed to describe episodic memory capabilities of the hippocampus in a spatial task. In th...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2021
ISSN: 0960-9822
DOI: 10.1016/j.cub.2021.03.003